Integrin beta 4 Antikörper

Produktnummer ABIN5540088

Der Maus Monoklonal Anti-Integrin beta 4 Antikörper wurde für WB, FACS, IP, IF, IHC (fro), ICC und EIA validiert. Er ist geeignet, Integrin beta 4 in Proben von Human zu detektieren.

Kurzübersicht für Integrin beta 4 Antikörper (ABIN5540088)

Target: Integrin beta 4 (ITGB4)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Integrin beta 4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Enzyme Immunoassay (EIA)

Klon: 58XB4

Produktdetails anti-Integrin beta 4 Antikörper

Spezifität: Binds specifically to integrin β4 chain(CD104) or β4 integrin, that associates with integrin α6 (CD49f) forms α6/β4 (CD49f/CD104) heterodimer. CD104 is expressed on epithelial cells (especially on the proliferative basal layer epithelial cells in skin), endothelial cells, Schwann cells, certain tumor cells and a subset of pre-T cells.

Aufreinigung: Purified

Immunogen: Immunization of Balb/c mice with Integrin beta4. The immunogen used to raise this antibody was the full length CD104 protein.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: ELISA. Western blotting. Immunofluorescence. Flow Cytometry. Immunoprecipitation. Imunocytochemistry of paraformaldehyde fixed cells. Immunohistochemistry on Frozen Sections. See Reference 1 for Protocols.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Buffer System: PBS Preservatives: 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freeze-thaw cycles. Shelf life: One year from despatch.

Details zu Integrin beta 4

Target: Integrin beta 4 (ITGB4)

Andere Bezeichnung: cd104,integrin beta-4

Hintergrund: Integrins are heterodimers composed of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. Integrin b4 (CD104) associates with integrin α6 (CD49f) forming the α6/β4 (CD49f/CD104) heterodimer. CD104 is expressed on epithelial cells (especially on the proliferative basal layer epithelial cells in skin), endothelial cells, Schwann cells, certain tumor cells and a subset of pre-T cells. CD49f/CD104 is an adhesion receptor for laminins (especially laminin 5) and keratin filaments and is involved in the regulation of hemidesmosome formation and of cell proliferation and activation. CD104 is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

UniProt: P16144

Pathways: Integrin Complex